If you're looking to discover somewhere new, look no further than Murphysboro. Whether you're planning to stay for a night or for the week, the area around Murphysboro has accommodation options to fit every need. Search for hotels in Murphysboro with Hotels.com by checking our online map. Our map displays the areas and neighbourhoods around all Murphysboro hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Murphysboro hotel deals are here with our lowest price guarantee.