Hotels in Upstate South Carolina

Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices

Check prices for these dates

This weekend
Next weekend

Where to stay in Upstate South Carolina?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Showing deals for:11 Jul - 13 Jul

Top landmarks in Upstate South Carolina

Learn more about Upstate South Carolina

Upstate South Carolina is applauded for its cultural attractions such as Heritage Park and CCNB Amphitheatre.

Photo by South Carolina Department of Parks, Recreation & Tourism
Open Photo by South Carolina Department of Parks, Recreation & Tourism

Check out reviews of Upstate South Carolina hotels guests love

Frequently asked questions

What hotels do travelers recommend in Upstate South Carolina?
Pettigru Place Bed & Breakfast, The Inn at Patrick Square and Residence Inn by Marriott Anderson Clemson are all properties that our guests really like.
Can I book a refundable hotel in Upstate South Carolina?
If you're looking for the flexibility to change your travel plans to Upstate South Carolina, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Which Upstate South Carolina hotels do our guests like for their terrific location?
Our guests love these properties for their convenient location: Best Western Plus Greenville I-385 Inn & Suites, La Quinta Inn & Suites by Wyndham Greenville Haywood and Spartanburg Marriott.
Where should I stay in Upstate South Carolina if I want a cheap accommodation?
A few inexpensive options worth considering are Best Western Plus Greenville I-385 Inn & Suites, La Quinta Inn & Suites by Wyndham Greenville Haywood and Comfort Inn Greenville - Haywood Mall. You can browse more choices on our site, including 30 motels.
Where can I stay in Upstate South Carolina if I want a vacation rental instead of a traditional hotel?
If you're looking for a good alternative to a hotel, review our selection of 1073 vacation homes. In addition, there are 111 apartments and 92 condos.
Why should I book my Upstate South Carolina hotel through Hotels.com?
There are lots of reasons to book your Upstate South Carolina trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Keep exploring

Keep exploring